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Research Fellows Directory

Christopher Rodgers

Dr Christopher Rodgers

Research Fellow


University of Oxford

Research summary

High-energy phosphorus (31P) containing metabolites (e.g. ATP, ADP and phosphocreatine) are critical to energy flow in the heart. Their occurrence in the heart has been studied by 31P magnetic resonance spectroscopy (31P-MRS) since 1974. One can obtain the spectrum from a localized region of tissue, from which the concentrations of metabolites are calculated and which in turn gives insight into biology. In humans in vivo, technical challenges have hitherto limited the clinical applicability o f 31P-MRS. To realise the longstanding goal of obtaining quality 31P spectra covering all 17 segments of the heart in under 20 minutes, every stage in the protocol must be optimised. Therefore, I propose to address the hardware used for cardiac 31P-MRS, the acquisition pulse sequence, the reconstruction of the acquired data and the post-processing of spectra to estimate metabolite concentrations. In the first instance, I will employ the UK's first cardiac-capable 7T MRI scanner to acquire spe ctra from calibration standa

Interests and expertise (Subject groups)

Grants awarded

Advanced human cardiovascular magnetic resonance spectroscopy.

Scheme: Sir Henry Dale Fellowship

Dates: Oct 2012 - Oct 2017

Value: £684,244