Scheme: Sir Henry Dale Fellowship
Organisation: University of Oxford
Dates: Sep 2013-Sep 2018
Summary: The project is aimed at understanding how brain activity is altered after local damage, as for example that occurring after a stroke, and how these changes relates to behavioural problems. An influential theory suggests that behavioural deficts after brain damage result from an altered interaction between areas in the brain (altered brain connectivity), even between pairs of areas that are far from the lesion. The link between behavioural deficits and altered brain connectivity, however, is stil l unclear. To advance current understanding, this research will use a unique converging set of approaches based on (i) analyses of the effects of controlled brain lesions in monkeys, (ii) modelling the effects of local injury on brain activity in intact regions. The proposed research is expected to advance our understanding of how brain lesions affect behaviour whilst also having applications into predicting how the effects of the injury can be remediated by appropriate treatment.