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Dante Mantini

Dr Dante Mantini

Dr Dante Mantini

Research Fellow

Interests and expertise (Subject groups)

Grants awarded

Large-scale alterations of cortical activity induced by brain lesions and their relevance to behavioural deficits.

Scheme: Sir Henry Dale Fellowship

Organisation: University of Oxford

Dates: Sep 2013-Sep 2018

Value: £1,458,494

Summary: The project is aimed at understanding how brain activity is altered after local damage, as for example that occurring after a stroke, and how these changes relates to behavioural problems. An influential theory suggests that behavioural deficts after brain damage result from an altered interaction between areas in the brain (altered brain connectivity), even between pairs of areas that are far from the lesion. The link between behavioural deficits and altered brain connectivity, however, is stil l unclear. To advance current understanding, this research will use a unique converging set of approaches based on (i) analyses of the effects of controlled brain lesions in monkeys, (ii) modelling the effects of local injury on brain activity in intact regions. The proposed research is expected to advance our understanding of how brain lesions affect behaviour whilst also having applications into predicting how the effects of the injury can be remediated by appropriate treatment.

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