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Fellows Directory

David Gadsby

Professor David Gadsby FRS

Fellow


Elected: 2005

Biography

David Gadsby is a cell physiologist who is renowned for his work on the proteins found in cell membranes. Such proteins typically act as pumps or channels that move substances in or out of cells. Although initially considered to be unrelated entities, David’s work overturned this view to suggest that these two types of conduit are more closely related.

His research focuses on the mechanism and structure of the sodium–potassium pump, found in all eukaryotic cells and responsible for maintaining their normal state. He has also defined a more detailed structure, and mechanism of action, of the cystic fibrosis transmembrane conductance regulator protein. Mutations in this cell membrane channel are responsible for the disease cystic fibrosis.

David is Patrick A. Gerschel Family Professor and Head of the Laboratory of Cardiac and Membrane Physiology at the Rockefeller University. He has published around 80 papers in his field and received a number of awards, including the Cole Award of the Biophysical Society in 1995, and a MERIT Award from the National Institutes of Health in 1998.

Professional positions

Patrick A Gerschel Family Professor and Head, Laboratory of Cardiac and Membrane Physiology, Rockefeller University

Interests and expertise

Subject groups

Keywords

ATPases, Electrophysiology, Ion channels, Ion pumps, Membrane protein structure and mechanism