Research Fellows Directory
Professor David Klenerman FMedSCi FRS
University of Cambridge
Neurodegenerative diseases such as Alzheimer' s and Parkinsons disease are a major problem as our population live for longer. However we still do not know the molecular cause of these diseases, which makes it hard to design any effective therapies. Small soluble protein aggregates are believed to play a key role in the initiation and spreading of these diseases.We are developing new sensitive methods to detect , characterise and image these aggregates that can be easily applied to human samples, such as cerebral spinal fluid, in order to identify which species are responsible for causing these diseases in humans. In the longer term this should allow us to rationally design therapies that target the real species that cause disease in humans and may also have potential for early disease diagnosis and to monitor the effectiveness of therapies.
Interests and expertise (Subject groups)