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Research Fellows Directory

Deepak Chand

Mr Deepak Chand

Research Fellow

Organisation

University of Cambridge

Research summary

My broad interest is to understand the transport process across the membrane. Mitochondria is one of the specialized compartment of the cell.

Mitochondria are often referred to as the power-stations of the human cell, where breakdown products of sugars and fat are used to make a cellular fuel called ATP. Every day we have to make our own body weight in ATP to sustain all of the energy-requiring processes in our cells. The mitochondrial ADP/ATP carrier is a key component of the recycling process of ATP. The carrier imports ADP, the spent fuel, into the mitochondria, where it is converted back into ATP using the energy extracted from sugars and fat. The carrier then exports the newly synthesized ATP out from the mitochondria. The mitochondrial ADP/ATP carriers belong to a large family of transport proteins in mitochondria, which play key roles in many aspects of cell physiology and are implicated in a growing number of severe neuromuscular and metabolic diseases. Here we propose to study the transport process in atomic detail in order to understand how it works and how its dysfunction leads to these diseases.

Interests and expertise (Subject groups)

Grants awarded

The structures of the substrate free and bound states of the mitochondrial ADP/ATP carrier

Scheme: Newton International Fellowships

Dates: Feb 2018 - Jan 2020

Value: £99,000

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