Edward (Eddie) Holmes is an evolutionary biologist distinguished for his work on the emergence and evolution of viruses. He has used genomic and phylogenetic approaches to reveal the major mechanisms of virus evolution and determined the genetic and epidemiological processes that explain how viruses jump species boundaries and spread in new hosts.

His work has revealed the origin, evolution and molecular epidemiology of important human pathogens including influenza, HIV and dengue, and enabled more accurate assessments of what types of virus are most likely to emerge in human populations and whether they will evolve human-to-human transmission. His recent research has provided fundamental insights into the breadth and biodiversity of the viral world.

Eddie is currently a Professor in the School of Life and Environmental Sciences and Sydney Medical School at the University of Sydney, located in the Charles Perkins Centre. In 2003 he was awarded the Scientific Medal of the Zoological Society of London and in 2015 was elected a Fellow of the Australian Academy of Science.