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Research Fellows Directory

Edward Louis

Professor Edward Louis FSB

Research Fellow

Organisation

University of Nottingham

Research summary

I work mostly with baker's or brewer's yeast as a model organism for many basic biological principles. In addition we use yeast to help clone difficult regions from other organisms of interest, most importantly various parasites such as those that cause malaria and sleeping sickness. Although we study the whole genome, we are particularly interested in the regions near the ends of the chromosomes. These are called subtelomeres and have interesting properties in yeast, parasites and even humans. For the most part the region has genes involved in interacting with the environment. For yeast these are genes that take up and metabolise sugars for fermenting into alcohol. For parasites these are genes that help them escape the immune system. For humans these include the receptors for smelling different smells. In virtually all the cases there are special dynamic properties that make the subtelomeres different from the rest of the genetic material. I have been studying this region in order to understand how the region is different and how it is kept under control. These studies help in understanding how some yeast are better for bread and others for beer, how different parasites cause disease and escape our defenses, and even how some diseases such as familial mental retardation come about.

Grants awarded

Telomere structure, function, dynamics and evolution from yeast to parasites

Scheme: Wolfson Research Merit Awards

Dates: Jan 2008 - Dec 2012

Value: £60,000