Dr Michael Harvey Hastings FRS
Staff Scientist, MRC Laboratory of Molecular Biology, Cambridge.
Michael Hastings is distinguished for his highly influential contributions to out understanding of biological clocks through the study of the suprachiasmatic nucleus (SCN) of the hypothalamus. He was instrumental in taking circadian neurobiology to the molecular and cell biological level. Hastings extended to mammals the clock model based on transcriptional negative feedback loops and identified important differences with the original Drosophila model. He unravelled the powerful influence of the SCN on the mammalian transcriptome and established it relevance for medicine. In pioneering studies, Hastings discovered the importance of intercellular signalling for intracellular clock function, defining the SCN as neuronal circuit.