Geoffrey Burnstock has made major contributions to our knowledge of the structure, function and pharmacology of the autonomic nervous system. In 1972, Geoffrey presented a hypothesis that ATP is a neurotransmitter involved in non-cholinergic, non-adrenergic transmission in the gut and bladder, and coined the term ‘purinergic transmission’.
In 1976, he made the novel proposal that nerves may release more than one transmitter and that ATP is a co-transmitter in most peripheral and central neurons. In 1978, he identified separate purinergic receptors (purinoceptors) for adenosine (P1) and ATP (P2) and, in 1985, P2X and P2Y subclasses. Cloning experiments confirmed P2X (ionotropic) and P2Y (metabotropic) receptors. Purinergic signalling was shown to be important in control of vascular tone and remodelling, bone, kidney, lung and bladder function, mechanosensory transduction and embryonic development.
Recently, the emphasis has been on translational research together with clinicians and industry to examine the pathophysiology and therapeutic potential of purinergic drugs for the treatment of disease, including thrombosis, pain, cystic fibrosis, arthritis, atherosclerosis, chronic cough, gut, bladder, kidney and bone disorders and cancer.
Honorary Professorial Fellow, Department of Pharmacology and Therapeutics, University of Melbourne
Autonomic nervous system,
P2X and P2Y purinoceptors,