Research Fellows Directory
Professor Gerard Evan FRS, FMedSci
University of Cambridge
Cancers are complex diseases involving hundreds of mutations, each of which may contribute to the final neoplastic phenotype. However, identifying which of this legion of mutations is required for maintenance of the cancer - i.e. whose inhibition would trigger regression of the tumor and effect a cure - continues to elude us. We have taken a different approach: the huge number of driver mutations in human cancers obscures a simple fact - almost all of them converge on a very restricted set of effectors. We term these the "engines" of cancer. We are using sophisticated switchable genetic models (that allow us to toggle genes on an off at will in tumors and normal adult tissues) to ascertain the therapeutic impact of inhibiting such engines. Our data show that interrupting these common engines has a profound and general therapeutic impact on most, perhaps all cancer types.
Interests and expertise (Subject groups)