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Research Fellows Directory

Guillaume De Bo

Dr Guillaume De Bo

Research Fellow


University of Manchester

Research summary

Mechanical force is a formidable, and relatively unexplored, source of energy that, with its ability to distort, bend and stretch chemical bonds, is unique in the way it activates chemical reactions. The precise control of this force could revolutionise how we build and rearrange molecular structures and change the way we think about chemical transformations. Precise control of this force can be achieved when the chemical entity that is the subject of the mechanical force (a mechanophore) is embedded within a polymeric backbone. Indeed, pulling both ends of a macromolecule apart creates a highly directional strain with its highest intensity in the middle of the chain. This technique has led to some remarkable results but has proved of modest practical use because the molecules of interest have to be removed from the polymeric backbone after reaction. The aim of this project is to design, synthesize and study new mechanophores that can catalytically harness mechanical energy to induce chemical transformations.

Interests and expertise (Subject groups)

Grants awarded

Harnessing mechanical force for synthesis

Scheme: University Research Fellowship

Dates: Jan 2016 - Dec 2020

Value: £473,558.65

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