Scheme: University Research Fellowship
Organisation: University of Liverpool
Dates: Oct 2008-Sep 2011
Summary: I am interested in how cells organise their communication systems. Like our own society, cells rely on specialised machinery to transmit signals from one place to another. To make this more efficient different components are brought close together in readiness for when a message needs to be sent. There are typically several versions of each component to allow different messages to be created. Some of these components are found in multiple locations within a cell, others are much more restricted in their distribution. This provides an opportunity for sending different messages depending on where the signal starts from due to the different signalling combinations present in each location.
In order to investigate this phenomenon we use the Ras signalling protein family as a model system. Activating mutations in the Ras pathway contribute to the development of the majority of cancers. There are three members of this family that are almost identical and found in every cell yet are able to signal differently. Work from my lab and others has shown that this is likely to be due to small differences in their localisations within cells. Using a variety of approaches we are investigating how these differences in localisation are achieved and to what extent signalling from each of these locations produces different outputs.
Dates: Oct 2003-Sep 2008
Summary: This project summary is not available for publication.