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Fellows Directory

Irwin McLean

Professor Irwin McLean FMedSci FRS


Elected: 2014


Twitter @IrwinMcLean


ORCID 0000-0001-5539-5757


Irwin McLean is investigating the genetic basis of inherited skin diseases. His primary interest lies in the gene that encodes filaggrin, a protein that binds to keratin fibres in epithelial cells and plays a significant role in maintaining the hydration and barrier function of the skin.

Mutations in the filaggrin gene — found in 10 per cent of the UK population — hinder the production of filaggrin protein and lead to a dry, flaky skin condition known as ichthyosis vulgaris. Irwin showed that people with such mutations are at much greater risk of developing atopic eczema and other allergic diseases; without filaggrin, the skin is a less effective barrier to pathogens, allergens and irritants — triggering an immune response.

Additionally, Irwin has identified the individual genes that cause over 20 other disorders affecting epithelial cells and tissues, including the skin. He is also heavily involved in small molecule drug discovery and is developing new RNA-based therapies to treat some of these previously identified disorders.

Professional positions

Professor of Human Genetics and Head of the Division of Molecular Medicine, Division of Molecular Medicine, University of Dundee

Interests and expertise

Subject groups


Allergy immunotherapy, Antisense RNA, Asthma, Atopic dermatitis, Corneal disorders, Dermatology, Drug discovery, Epidermis, Epithelial cells, Epithelium, filaggrin, genodermatoses, Human genetics, Keratinocytes, Keratins, oligonucleotide therapy, skin barrier, Small interfering RNAs, transgenics


  • Buchanan Medal

    For his major contribution to our understanding of the genetic basis of heritable skin diseases.