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Research Fellows Directory

Isaac Bianco

Dr Isaac Bianco

Research Fellow

Organisation

University College London

Research summary

The brain allows animals to interpret stimuli they encounter in their environment and respond with appropriate behaviours. My aim is to understand the complete brain circuitry that enables larval zebrafish to hunt and capture their prey. Larval zebrafish have a typical vertebrate brain organisation but they are small and optically transparent. This allows fluorescence microscopy to be used to image the activity of every nerve cell in the brain, whilst the animal responds to artificial prey-like visual cues presented on a miniature screen. To experimentally test the importance of these activity patterns, I will use genetically-modified fish in which the activity of ensembles of nerve cells can be precisely manipulated with light. This will enable me to 'replay' portions of the brain activity pattern and test how information processing and behaviour are affected. In addition, various techniques will be used to examine the molecular properties of nerve cells and elucidate the wiring diagr am of the circuit. In

Interests and expertise (Subject groups)

Grants awarded

From vision to action: Systems analysis of sensorimotor circuitry controlling visually-guided behaviour.

Scheme: Sir Henry Dale Fellowship

Dates: Oct 2013 - Oct 2018

Value: £1,118,346

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