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Research Fellows Directory

Isabel Cruz-Gallardo

Dr Isabel Cruz-Gallardo

Research Fellow

Organisation

King's College London

Research summary

In every single cell of our bodies, RNA provides the messenger that carries the DNA code information of the nucleus into the cytoplasm, where the proteins are made. However, it turns out that RNA has many other roles and the interplay between RNA-binding proteins (RBP) and RNA molecules is now known to be central to the life of all cells and organisms. Nonetheless the roles of most RNA-binding proteins remain unknown.

LARP4 is a newly discovered RBP that affects mRNA stability and has been identified as a regulator of cell morphology and migration. Since aberrant cell migration contributes to the development of human diseases including cancer, chronic inflammation and atherosclerosis, LARP4 represents an excellent RBP to advance our understanding of key cellular mechanisms relating to mRNA processing and turnover.

The overall aim of my research is to understand at a molecular level how LARP4 regulates mRNA translation and how this impacts on cell migration, especially in the context of cancer cell biology, using human prostate cancer cell lines as models. For this, a multidisciplinary approach combining biochemistry, biophysics, structural and cell biology is used.

Interests and expertise (Subject groups)

Grants awarded

Structure and functional studies to elucidate the role of LARP4 in cell migration

Scheme: Newton International Fellowships

Dates: Jan 2015 - Aug 2016

Value: £101,000

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