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Research Fellows Directory

Iwan R Evans

Dr Iwan R Evans

Research Fellow

Organisation

University of Sheffield

Research summary

Fruit flies contain a population of immune cells responsible for finding, eating and disposing of dying cells and invading bugs. These fruit fly cells carry out many roles in common with cells of our own immune system and so we can use them to understand the functions of immune cells using non-invasive techniques within a much simpler living animal. Researchers have used these flies for over 100 years, so that an array of sophisticated tools exists to help understand the genes required for norma l (and abnormal) immune cell behaviour. We can image these cells very clearly, allowing us to see alterations in their behaviour easily. By manipulating the interactions between immune cells and cells undergoing a form of death, called apoptosis, I will be able to understand how apoptosis affects immune cell functions. Too much apoptosis suppresses immune cell movements, including to wounds, and I aim to identify the underlying mechanism for this phenomenon. My work will also identify new pathwa ys involved in the det

Grants awarded

Studying integration of apoptotic cell clearance and macrophage migration dynamically in vivo.

Scheme: Sir Henry Dale Fellowship

Dates: Jan 2014 - Jan 2019

Value: £930,801