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Research Fellows Directory

James A Harker

Dr James A Harker

Research Fellow


Imperial College London

Research summary

Infectious diseases account for 33 million deaths a year, mostly of children and the elderly. Respiratory viruses in particular represent a major challenge, accounting for approximately 90% of infant hospitalizations in the developed world, which are primarily caused by respiratory syncytial virus (RSV) infection. Respiratory viral infections such as RSV and influenza A virus infections are also major causes of illness and mortality in the elderly. Vaccination is the primary method for the prev ention of illness as a result of infection; unfortunately effective vaccines against many infections, including RSV, remain elusive. This is of increased importance in the young and the elderly where it has proven especially difficult to successfully vaccinate. I have identified the role of a specific family of molecules during infection which promote a response important in the protection of individuals during vaccination. I propose to use my knowledge of these molecules, and their function, to determine their role i

Grants awarded

Contextual manipulation of the IL-6 family of cytokines to alter and enhance CD4+ T cell immunity to respiratory viral infections.

Scheme: Sir Henry Dale Fellowship

Dates: Aug 2013 - Aug 2018

Value: £1,073,815

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