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Research Fellows Directory

James Moore

Professor James Moore FAIMBE, FASME

Research Fellow


Imperial College London

Research summary

The view that the body is an incredible machine is particularly relevant for the

vascular system. It is responsible for delivering nutrients to all of the body’s

tissues and then removing waste products. It performs this function with a

miraculous combination of pumps, pipes and different fluids. My research focuses

on understanding the fantastic biomechanical aspects of this system, then using

that information to design disease treatment technologies that are both clinically

and economically more effective.

The vascular system is composed of arteries, veins and lymphatic vessels. Blood

is carried away from the heart by arteries to the capillaries (where important mass

transfer processes take place) and then is returned by the veins. There is a net

loss of fluid and proteins at the capillary level that is taken up by the lymphatic

system. The fluid is these vessels (lymph) is largely aqueous and contains

important cells for immune function.

The diseases associated with the vascular system are the most common causes

of death in the world, and include atherosclerosis and cancer. Atherosclerosis is

the gradual narrowing of an artery that eventually restricts blood flow, resulting in

tissue death. Commonly affected tissues include the heart (myocardial infarctions,

or heart attacks) and the brain (strokes). As cancerous tumors develop, their cells

can escape into the lymphatic system. While lymph nodes are equipped to deal

with these metastases, this system can be overwhelmed, resulting in cancer

spreading to other parts of the body. For this reason, parts of the lymphatic

system in cancer patients are removed surgically. While this generally helps with

the cancer prognosis, it can restrict the normal return of lymph and lead to

oedema, characterised by local, painful swelling of tissues. There is no effective

cure for oedema.

Grants awarded

Vascular Biomechanics and Medical Device Development

Scheme: Wolfson Research Merit Awards

Dates: Jan 2013 - Dec 2017

Value: £65,000