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Fellows Directory

Jamshed Tata

Jamshed Tata

Dr Jamshed Tata FRS

Fellow


Elected: 1973

Biography

Jamshed Tata is an endocrinologist and developmental biologist whose research has revealed much about the cellular and molecular actions of thyroid and other hormones. Critical for vital processes during development and in adulthood, Jamshed was the first to show that thyroid hormone has a direct effect on gene expression.

Born and educated in Bombay, he began his research career in Paris and changed scientific thinking on how thyroid hormone acts on cells to raise the basal metabolic rate. Although the consensus at the time suggested that thyroid hormone interfered with mitochondrial energy production, Jamshed proved that, in fact, it regulated the activity of genes.

Jamshed subsequently began to study metamorphosis in amphibians, a process in which thyroid hormone was known to be involved. Once again, he overturned an earlier theory by showing that as tadpoles develop into frogs, thyroid hormone controls gene expression to stimulate the loss of the tail. In addition, he played a role in demonstrating the multiplicity of RNA polymerase.

Interest and expertise

Subject groups

  • Biochemistry and molecular cell biology
    • Cell biology (incl molecular cell biology)
  • Anatomy, physiology and neurosciences
    • Physiology incl biophysics of cells (non-clinical)
  • Microbiology, immunology and developmental biology
    • Developmental biology

Keywords

hormone action, nuclear hormone receptors, hormonal regulation of development, programmed cell death, amphibian metamorphosis, gene expression, mitochondria

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