Scheme: Wolfson Research Merit Awards
Organisation: University of Birmingham
Dates: May 2006-Apr 2011
Summary: Hepatitis C Virus (HCV) is a major cause of liver disease worldwide. The majority of infections are not cleared, resulting in a slowly progressive chronic liver disease, that is one of the leading indications for liver transplantation. Recent advances in the development of systems to culture HCV in the laboratory and to image living cells have enabled us to study the very early events defining virus entry into the liver. Understanding how HCV infects cells and evades host neutralizing antibody responses is an essential prerequisite both for vaccine design and for the development of therapeutic agents.