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Research Fellows Directory

John Bower

Dr John Bower

Research Fellow

Organisation

University of Bristol

Research summary

A key goal of organic synthesis is the ability to selectively form one of the two possible mirror images of a chiral compound. This is of huge importance because the different mirror images have very different effects in biological systems. Many methods have been developed over the last several decades, but these are often inefficient, requiring multiple synthetic steps and generating significant quantities of waste. My research focuses on the development of catalysis to provide a solution to this challenge. My group designs new catalysts with "enzyme like" properties, which are able to achieve selectivity with minimal or no waste. The broad aim is to provide catalytic methods that use starting materials which are the direct products of bulk chemical manufacture. This removes the requirement for extra synthetic manipulations prior to the key mirror image selection step, thereby mitigating issues associated with cost and waste. The new methods developed in my laboratory may find use in the development of pharmaceuticals and agrochemicals.

Interests and expertise (Subject groups)

Grants awarded

New enantioselective metal-catalysed C-N and C-C bond forming reactions

Scheme: University Research Fellowship

Dates: Oct 2015 - Sep 2018

Value: £307,608.94

Activated Oximes as Agents for Transition-Metal Catalysed C-N Bond Formation

Scheme: University Research Fellowship

Dates: Oct 2010 - Sep 2015

Value: £496,786.88

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