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Research Fellows Directory

K. Ravi Acharya

Professor K. Ravi Acharya

Research Fellow

Organisation

University of Bath

Research summary

Modern biology is always looking for improvement by incorporating the latest

technologies to further refine our knowledge of life. More and more its research

must have solid applications at a time when science holds the key to the future.

Structural molecular biology (an interdisciplinary science) has been on top of

these advances, combining physics, chemistry, mathematics and biology, to

produce some of the best scientific breakthroughs of the twentieth century.

Structural biology is constantly evolving and feeding from its own discoveries,

promising to provide essential information on nucleic acids, proteins and their

complexes.

Proteins are essential molecules of all living organisms, carrying out most of the

function in a living cell. Their variety of activity and interactions with other

biological components make a fascinating subject for investigation. Furthermore,

proteins are often involved in pathological processes, understanding their

molecular mechanism and structural alteration are therefore critical in finding new

approaches to fight diseases.

Projects in my laboratory consist of studying proteins with new therapeutic

interests to understand their mechanisms of action and help engineer new drug

compounds for human diseases. Using state-of-the- art technology and equipment

in protein X-ray crystallography, we can look in detail into the 3D structure of

complex macromolecules at atomic level. X-ray crystallography is a unique

technique in giving detailed information of molecules which can be used by all

who have interests in biological processes. Armed with this information novel

drugs can be designed that target a particular protein, or enzymes can rationally

be engineered for specific industrial processes.

Grants awarded

An investigation into novel therapeutics based on Clostridial Neurotoxins

Scheme: Industry Fellowship

Dates: Oct 2007 - Sep 2011

Value: £154,130.24