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Research Fellows Directory

Kevin Waldron

Dr Kevin Waldron

Research Fellow

Organisation

Newcastle University

Research summary

Copper and silver have received recent attention for their antimicrobial properties. Clinical trials, where hospital stainless steel fixtures were replaced with copper-containing alloys, showed 60-70% reduction in bacterial load. Copper has been used as an agricultural antifungal since the 19th century, and is used as an antibacterial growth promoter and post-slaughter preservative for livestock. Recent data also show that copper is important in the immune system's defence against invading bacte ria. Yet the mechanisms by which copper or silver cause toxicity against microorganisms are unknown. My preliminary analyses demonstrate the presence of unexpected (and unpredicted) copper-associated proteins in soluble extracts from the model pathogen Staphylococcus aureus (the bacterium of MRSA) when cultured under 'standard' (ie low copper) conditions. I will identify these proteins using established methods, and then determine the role that copper-binding plays in their cellular function. Finally, proteins will b

Interests and expertise (Subject groups)

Grants awarded

Mechanisms of copper and silver toxicity in Staphylococcus aureus.

Scheme: Sir Henry Dale Fellowship

Dates: Oct 2012 - Oct 2017

Value: £697,499