Research Fellows Directory
Kuan Boone Tan
Dr Kuan Boone Tan
University College London
My research is focused on the rational design and development of various nanomaterials for biomedical applications. I have been developing nanoscale liposome systems for delivering synergistic anti-cancer drug combinations. This approach is based on the use of nanocarriers to coordinate the pharmacokinetics and synchronise release of drugs to maintain the synergistic drug ratio which holds great promises for improved cancer therapy. My current research focuses on the development of a novel nanomaterial as scaffold for ex vivo expansion of HSPC in umbilical cord blood (UCB). Haematopoietic cell transplantation is a developing therapy for many patients with haematological malignancies and other life-threatening blood disorders. Today, these therapies can, in part, utilise UCB as a valuable source of haematopoietic stem and progenitor cells (HSPC). Unfortunately, UCB cell numbers are generally low, and so require ex vivo expansion to boost the cell yields for therapy. Here in, a new approach is sought to improve cell yields using novel magnetic carbon nanotube (CNT) scaffolds. The magnetic components will assist with the carbon nanotube removal, and thus circumvent current in vivo complications associated with carbon nanotubes in the body. In this project, the physicochemical properties of the magnetic CNT scaffolds and in vitro functionality of the expanded HSPC will be comprehensively studied.
Interests and expertise (Subject groups)