Research Fellows Directory
Professor Malcolm White FRSE
University of St Andrews
Our lab is focussed on the molecular biology and evolution of proteins and pathways that manipulate nucleic acids, including helicases, nucleases and recombinases. We have particular interests in the CRISPR-Cas system of antiviral defence and DNA repair mechanisms . We utilise a combination of structural, molecular and micro-biology, biochemistry and bioinformatics.
The expertise within the Biomedical Sciences Research Complex allows us to utilise a wide variety of techniques including single-molecule TIRF microscopy, spectroscopy and X-ray crystallography in these studies. Structure-function studies of archaeal repair proteins have important implications for the equivalent proteins in humans. The CRISPR-Cas system is a fascinating aspect of prokaryotic molecular biology with many fundamental research questions and exciting applications in genome engineering and biotechnology.
Interests and expertise (Subject groups)