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Malcolm White

Professor Malcolm White

Professor Malcolm White

Research Fellow

Interests and expertise (Subject groups)

Grants awarded

The CRISPR-Cas system for prokaryotic antiviral defence

Scheme: Wolfson Research Merit Awards

Organisation: University of St Andrews

Dates: Aug 2014-Jul 2019

Value: £75,000

Summary: Our lab is focussed on the molecular biology and evolution of proteins and pathways that manipulate nucleic acids, including helicases, nucleases and recombinases. We have particular interests in the CRISPR-Cas system of antiviral defence and DNA repair mechanisms . We utilise a combination of structural, molecular and micro-biology, biochemistry and bioinformatics. The expertise within the Biomedical Sciences Research Complex allows us to utilise a wide variety of techniques including single-molecule TIRF microscopy, spectroscopy and X-ray crystallography in these studies. Structure-function studies of archaeal repair proteins have important implications for the equivalent proteins in humans. The CRISPR-Cas system is a fascinating aspect of prokaryotic molecular biology with many fundamental research questions and exciting applications in genome engineering and biotechnology.

Scheme: University Research Fellowship

Organisation: University of St Andrews

Dates: Oct 1996-Sep 2005

Value: £178,871.11

Summary: Our lab is focussed on the molecular biology and evolution of proteins and pathways that manipulate nucleic acids, including helicases, nucleases and recombinases. We have particular interests in the CRISPR-Cas system of antiviral defence and DNA repair mechanisms . We utilise a combination of structural, molecular and micro-biology, biochemistry and bioinformatics. The expertise within the Biomedical Sciences Research Complex allows us to utilise a wide variety of techniques including single-molecule TIRF microscopy, spectroscopy and X-ray crystallography in these studies. Structure-function studies of archaeal repair proteins have important implications for the equivalent proteins in humans. The CRISPR-Cas system is a fascinating aspect of prokaryotic molecular biology with many fundamental research questions and exciting applications in genome engineering and biotechnology.

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