Scheme: Wolfson Research Merit Awards
Organisation: University of St Andrews
Dates: Aug 2014-Jul 2019
Summary: Our lab is focussed on the molecular biology and evolution of proteins and pathways that manipulate nucleic acids, including helicases, nucleases and recombinases. We have particular interests in the CRISPR-Cas system of antiviral defence and DNA repair mechanisms . We utilise a combination of structural, molecular and micro-biology, biochemistry and bioinformatics.
The expertise within the Biomedical Sciences Research Complex allows us to utilise a wide variety of techniques including single-molecule TIRF microscopy, spectroscopy and X-ray crystallography in these studies. Structure-function studies of archaeal repair proteins have important implications for the equivalent proteins in humans. The CRISPR-Cas system is a fascinating aspect of prokaryotic molecular biology with many fundamental research questions and exciting applications in genome engineering and biotechnology.
Scheme: University Research Fellowship
Dates: Oct 1996-Sep 2005