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Research Fellows Directory

Malcolm White

Professor Malcolm White FRSE

Research Fellow

Organisation

University of St Andrews

Research summary

Our lab is focussed on the molecular biology and evolution of proteins and pathways that manipulate nucleic acids, including helicases, nucleases and recombinases. We have particular interests in the CRISPR-Cas system of antiviral defence and DNA repair mechanisms . We utilise a combination of structural, molecular and micro-biology, biochemistry and bioinformatics.

The expertise within the Biomedical Sciences Research Complex allows us to utilise a wide variety of techniques including single-molecule TIRF microscopy, spectroscopy and X-ray crystallography in these studies. Structure-function studies of archaeal repair proteins have important implications for the equivalent proteins in humans. The CRISPR-Cas system is a fascinating aspect of prokaryotic molecular biology with many fundamental research questions and exciting applications in genome engineering and biotechnology.

Interests and expertise (Subject groups)

Grants awarded

The CRISPR-Cas system for prokaryotic antiviral defence

Scheme: Wolfson Research Merit Awards

Dates: Aug 2014 - Jul 2019

Value: £75,000

Scheme: University Research Fellowship

Dates: Oct 1996 - Sep 2005

Value: £178,871.11

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