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Research Fellows Directory

Matthias Marti

Professor Matthias Marti

Research Fellow

Organisation

University of Glasgow

Research summary

Our research area:

The Marti lab is investigating the biology of malaria transmission, with the aim to translate findings for diagnostic and intervention purposes.

The science:

A small proportion of asexually replicating malaria parasites switch to a non-replicative sexual cycle that culminates in the formation of transmission-competent mature gametocyte stages. Mature gametocytes are the only parasite that can be transmitted to the mosquito vector and therefore is essential for parasite survival. Gametocytes are genetically identical but undergo significant morphological differentiation during development while sequestered in tissues. Specific questions my lab is focusing on: i) what are the triggers and mechanisms underlying the switch from asexual replication to sexual development? ii) What are the mechanisms of parasite homing and sequestration in bone marrow? iii) What makes a parasite infectious to mosquitoes? We have been developing a series of genetic, molecular and diagnostic tools in the last years to systematically investigate these questions under controlled in vitro conditions, during human infection and in the rodent malaria model.

Possible applications/benefit:

The proposed research is perfectly aligned with the ongoing activities at Glasgow University and it will provide significant additional capacity in a critical research area.

Grants awarded

Stage differentiation in malaria parasites

Scheme: Wolfson Research Merit Awards

Dates: Jun 2016 - May 2021

Value: £100,000

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