Michael Crumpton is a biochemist who has conducted important research into the way our immune system reacts to the presence of foreign bodies. By examining how human antibodies bind with incoming antigens, he has helped to clarify the pivotal role played by molecular structure in interactions of this type.
Michael has focused his attention on the study of lymphocytes, and in particular the way in which antigens react with certain proteins found on the lymphocyte surface. The techniques he developed to isolate these proteins, which apply chromatography to liquid solutions of the surface membrane, have since become widely popular. His findings have improved our understanding of so-called MHC molecules that are expressed on the surface of all cells and play a major role in priming the human immune system.