Scheme: Wolfson Research Merit Awards
Organisation: University of Nottingham
Dates: Apr 2012-Mar 2017
Summary: High throughput screening has been used to discover a novel class of polymers with resistance to bacterial attachment and subsequent biofilm formation. We believe that bacterial decision-making is key to determining whether a surface is colonised or not. Early results from our optical microscopy investigations show of how individual bacterial cells respond to surfaces using both 3D microscopy to allows us to track not only the motion of single cells at the surface, but also their approach to and behaviour after contact with the surface. We will combine these findings with our understanding of the surface chemistry-attachment relationships for certain subsets of materials and attachment regimes with in situ chemical analysis to build a complete description of this complex biointerface and the response of bacteria to it. This information is crucial in determining how bacteria behave with respect to defined surfaces and has important implications for the prevention of device centred infections.