Research Fellows Directory
University of Oxford
My current research is focused on transition metal-catalysed domino reactions of alkenes and alkynes, and related mechanistic studies. These reactions involve the formation of multiple covalent bonds in a single step to construct elaborate polycyclic structures similar to those found in biologically active molecules:
Pd-catalysed enantioselective enyne cyclisations to form quaternary stereocenters via asymmetric counterion directed catalysis;
Mechanistic studies in Pd-catalysed Pauson-Khand reactions initiated by alkynoate chloropalladation;
Enyne cycloisomerisation / Diels-Alder reaction / lactonisation sequences as atom economic routes to fused carbocyclic lactones;
Developing new chiral dienes from extracts of Chinese plants for use in rhodium catalysis.
Interests and expertise (Subject groups)