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Research Fellows Directory

Nathalie L Rochefort

Dr Nathalie L Rochefort

Research Fellow


University of Edinburgh

Research summary

Our perceptions, thoughts and actions depend on the coordinated activity of billions of neurons in our brain. These electrically excitable cells are wired up into networks and communicate with each other through synapses. These networks are established during the development of the brain but some of their properties can be modified throughout our lives, giving us the ability to learn through experience. The objective of this proposal is to understand how neuronal circuits involved in visual per ception are modified by visual experience. Due to recent ground-breaking developments in imaging and genetic tools, it is now possible to use optical methods to image the activity of individual neuronal synapses in the living brain. In the context of this proposal, I will use such an imaging method, named two-photon calcium imaging, to determine how repetitive visual stimulation modifies the activity of synapses between specific classes of neurons. I will distinguish the activity of so-called ex citatory neurons from t

Interests and expertise (Subject groups)

Grants awarded

Neuronal circuits and synaptic mechanisms of experience-dependent plasticity.

Scheme: Sir Henry Dale Fellowship

Dates: Jan 2014 - Jan 2019

Value: £1,139,911

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