Ole Petersen is a medical doctor and physiologist whose research, in addition to uncovering the cellular mechanisms by which the secretion of digestive enzymes from the pancreas are controlled, has shown how excessive intracellular release and subsequent entry of calcium ions cause activation of digestive enzymes inside pancreatic cells. This process leads to acute pancreatitis and an increased risk of pancreatic cancer.
The pancreas secretes a cocktail of enzymes that normally become activated in the gut to help break down proteins, fat and carbohydrates. However, gallstones or an excessive intake of alcohol can lead to activation of these enzymes inside pancreatic cells, which then digest the pancreas itself.
Ole has shown that specific pharmacological inhibition of entry pathways for calcium ions markedly reduces the excess enzyme activity and subsequent cell death and inflammation. His significant research was acknowledged by the award of CBE in the 2008 New Year Honours, election to the German National Academy of Sciences Leopoldina in 2010, the Walter B. Cannon Award of the American Physiological Society in 2018, the Academia Europaea’s Gold Medal in 2020 and the International Association of Pancreatology's Palade Prize and Medal in 2022.
Professional position
- Professor, Cardiff School of Biosciences, Cardiff University
- Academic Director, Academia Europaea Cardiff Knowledge Hub, Academia Europaea
- Vice-President and Member of Executive Board, Academia Europaea
- Board Member, Science Advice for Policy by European Academies (SAPEA)
Subject groups
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Multicellular Organisms
Physiology incl biophysics of cells (non-clinical)
