Research Fellows Directory
Dr Pakorn Wattana-amorn
University of Bristol
My research group is interested in the area of natural products and structure biology. We use a variety of techniques from molecular biology to nuclear magnetic resonance (NMR) to understand the biosynthetic pathways of invaluable bioactive compounds. Currently we are working on the biosynthesis of macrocyclic polylactone, menisporosin A, produced by Menisporopsis theobromae BCC 4162. This compound shows a broad spectrum of biological activities such as antimalarial, antimycobacterial and cytotoxic activities. Identification of the genes responsible for the biosynthesis of menisporopsin A will allow us to understand the formation of this complex macrocyclic polylactone. Also, genetic manipulation of the biosynthetic gene cluster may lead to the formation of novel compounds with better biological activities comparing to menisporopsin A. This work is under collaboration with Dr. Colin Lazarus at School of Biological Sciences, University of Bristol.
Interests and expertise (Subject groups)