Bob Michell’s research has focused on understanding the biological functions of inositol phospholipids, or phosphoinositides, which are quantitatively minor phospholipid constituents of the membranes of eukaryotic cells. He recognised that receptor stimulation of inositol lipid hydrolysis is a widespread reaction that leads to intracellular mobilisation of Ca2+.
His research group identified hydrolysis of phosphatidylinositol 4,5-bisphosphate as the initiating reaction in this process. Later, they discovered a novel phosphoinositide, phosphatidylinositol 3,5-bisphosphate, for which important functions have since been recognised. Bob has also provided insights into the evolutionary origins of the inositol phosphates and phosphoinositides.
Emeritus Professor of Biochemistry, School of Biosciences, University of Birmingham Royal Society Research Professor, School of Biosciences, University of Birmingham
Interest and expertise
Biochemistry and molecular cell biology
Biochemistry and molecular biology
Inositol, Cell signaling, Phosphoinositide signal transduction
UK-Canada Rutherford Lecture
On 'Inositol lipids and phosphates in cell regulation'.