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Research Fellows Directory

Shukry Habib

Dr Shukry Habib

Research Fellow


King's College London

Research summary

Regenerative medicine holds great promise for improving human health by using stem cells to repair damaged tissues in the body or replace diseased tissue with healthy tissue. Stem cells have the ability to make more stem cells and also to give rise to more mature (differentiated) cells that maintain the body's tissues throughout our lives. Both process are key to normal tissue maintenance and repair. One mechanism to achieve both tasks is called asymmetric cell division (ACD). In ACD, the stem c ell divides and gives rise to one stem cell and one differentiated cell. The process of ACD was originally discovered in flies and worms and little is known about the mechanisms that control ACD in mammals. I have discovered that a protein called Wnt, when coated on beads and introduced to one side of a mammalian stem cell in culture induces ACD. To further explore this unique effect, I propose to analyze in detail the mechanism and the components involved in Wnt-mediated ACD. To gain insights i nto this process in th

Interests and expertise (Subject groups)

Grants awarded

The Molecular Mechanism of Wnt-mediated Asymmetric Stem Cell Division.

Scheme: Sir Henry Dale Fellowship

Dates: Dec 2013 - Dec 2018

Value: £1,200,000

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