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Research Fellows Directory

Simone Weyand

Dr Simone Weyand

Research Fellow

Organisation

University of Cambridge

Research summary

Clinical depression and other neurological disorders are a major cause of medical conditions worldwide. So far, relatively little is known about the source of these diseases, and the precise biochemical dysfunction at the molecular level remains poorly understood. At present, prescribed psychoactive drugs used for treatments interact on a broad level with strong side effects. Neurotransmitter transporters are involved in these disorders, because of their expression and localization in neuronal cell membranes. They present useful targets for CNS drugs and mutations in individual transporters could be co-associated with specific phenotypes. More than 20 different types of neurotransmitter transporters are responsible to transport neurotransmitters across the neuronal cell membrane and to direct their further transport to specific intracellular locations. The aim of this research is to achieve an in-depth understanding of the molecular transport mechanism of the norepinephrine and the do pamine transporters. T

Interests and expertise (Subject groups)

Grants awarded

Towards a molecular understanding of neurotransmitter transporter cellular activities.

Scheme: Sir Henry Dale Fellowship

Dates: Jul 2013 - Jul 2018

Value: £1,065,958