Research Fellows Directory
Dr Stefan Mommer
University of Cambridge
My current research is focused on thiolactone-modified hyaluronic acid polymers. The thiolactones at the hyaluronic acid backbone enable a simple double modification of the polymer. Thiolactones are strained cyclic active esters which allow the selective conversion with amines (e.g. amino acids or peptides). In a second modification step, a guest molecule for host-guest complexation is installed to the polysaccharide. The project aims, to use this final product polysaccharide for tissue engineering applications. Host-guest chemistry allows the cross-linking of these polysaccharides in a non-covalent fashion. The peptides are able to communicate and stimulate with surrounding cells. This hydrogel platform is investigated in relation to cell-hydrogel interactions.
Interests and expertise (Subject groups)