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Research Fellows Directory

Stephen Baker

Dr Stephen Baker

Research Fellow

Organisation

University of Oxford

Research summary

Shigella are bacteria that cause bloody diarrhoea. Shigella infections are prevalent in young children in developing countries. Data from our previous research shows a recent change in most common type of Shigella in developing countries. This is a concern, as the bacteria are evolving rapidly and becoming highly resistant to antibiotics. Therefore, we wish to study the emergence of these bacteria in developing countries. However, there is no vaccine and we do not understand how the organisms ar e transmitted, how the organisms are evolving, how many people get infected or how the immune system recognises the bacteria. This project aims to tackle these issues. A collection of >1,000 Shigella from infected children in Ho Chi Minh City will be gathered, the bacterial DNA will be decoded and related to antibiotic resistance and their time and place of isolation. How and how many children get Shigella will be calculated by assessing all diarrhoeal infections in 1,000 children over a two yea r period. We will eval

Grants awarded

The epidemiology, genomics and longitudinal immune response of Shigella infections in Vietnamese children.

Scheme: Sir Henry Dale Fellowship

Dates: Mar 2013 - Mar 2018

Value: £1,569,817

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