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Research Fellows Directory

Stephen Graham

Dr Stephen Graham

Research Fellow


University of Cambridge

Research summary

Human cells are subdivided into multiple compartments with distinct chemical environments, thereby allowing distinct (and potentially non-compatible) chemical processes to take place simultaneously. However, this compartmentalisation presents the cell with a logistical dilemma: How can it transport cellular components between compartments? The cell has tackled this problem by evolving a complex system of intracellular trafficking that is tightly regulated to ensure only the right compartments fuse and thereby allow mixing of their contents. I am interested in how this fusion step of intracellular trafficking is regulated, as aberrant regulation of fusion leads to numerous human pathologies. I will purify the proteins that regulate intracellular compartment fusion, map interaction networks between these protein and solve their structures at atomic resolution in order to build up a molecular model of how intracellular compartment fusion is regulated. I am also interested in how huma n pathogens such as vi

Interests and expertise (Subject groups)

Grants awarded

Molecular mechanisms of membrane trafficking in pathology and infectious disease.

Scheme: Sir Henry Dale Fellowship

Dates: Oct 2012 - Oct 2017

Value: £834,695