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Stephen Graham

Dr Stephen Graham

Dr Stephen Graham

Research Fellow

Interests and expertise (Subject groups)

Grants awarded

Molecular mechanisms of membrane trafficking in pathology and infectious disease.

Scheme: Sir Henry Dale Fellowship

Organisation: University of Cambridge

Dates: Oct 2012-Oct 2017

Value: £834,695

Summary: Human cells are subdivided into multiple compartments with distinct chemical environments, thereby allowing distinct (and potentially non-compatible) chemical processes to take place simultaneously. However, this compartmentalisation presents the cell with a logistical dilemma: How can it transport cellular components between compartments? The cell has tackled this problem by evolving a complex system of intracellular trafficking that is tightly regulated to ensure only the right compartments fuse and thereby allow mixing of their contents. I am interested in how this fusion step of intracellular trafficking is regulated, as aberrant regulation of fusion leads to numerous human pathologies. I will purify the proteins that regulate intracellular compartment fusion, map interaction networks between these protein and solve their structures at atomic resolution in order to build up a molecular model of how intracellular compartment fusion is regulated. I am also interested in how huma n pathogens such as vi

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