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Fellows Directory

Vincenzo Cerundolo

Vincenzo Cerundolo

Professor Vincenzo Cerundolo FMedSci FRS

Fellow


Elected: 2018

Biography

Vincenzo Cerundolo is distinguished for his discoveries in processing and presentation of peptides and lipids to T cells. He was first to demonstrate that TAP genes within the major histocompatibility complex (MHC) transport peptides presented by MHC class I molecules and describe a novel clinical syndrome in patients with defective TAP genes. Cerundolo characterised the relationship between the length of peptides and their binding affinity to MHC class I molecules, explaining the homogeneous length of peptides isolated from MHC class I molecules.

He demonstrated that proteasome dependent degradation of antigenic proteins plays a key role not only in controlling presentation of intracellular, but also of extracellular proteins taken up byantigen presenting cells, hence defining the mechanism for the process known as cross-presentation.

He characterised the structural and kinetic mechanisms by which lipids bind to CD1 molecules and are recognized by T cells and demonstrated that harnessing CD1 restricted NKT cells enhances antigen specific antibody and T cell responses. These seminal findings have opened up novel therapeutic strategies to enhance immune responses against cancer and pathogens.

Professional positions

Director, MRC Human Immunology Unit, University of Oxford

Interest and expertise

Subject groups

  • Microbiology, immunology and developmental biology
    • Cellular and humoral immunology

Keywords

Cancer immunity, Antigen Processing and Presentation

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