Walter Gilbert is a Nobel Prize-winning scientist who started his career in theoretical physics before moving to molecular biology, working hard to compensate for his lack of formal training in the field. Walter has made many major discoveries concerning gene control and nucleic acids and is best known for devising one of the first methods of DNA sequencing.
Knowledge of DNA sequences is instrumental for basic biological research as well as applied fields such as diagnostic, biotechnology and virology. In the mid-1970s, Walter and Allan Maxam found a way to determine the precise sequence of nucleotide ‘links’ in the chainlike molecules of nucleic acids, using radioactive labelling. The resulting Maxam–Gilbert sequencing proved popular as it offered certain advantages over the Sanger dideoxynucleotide method.
Walter was awarded the 1980 Nobel Prize in Chemistry for his pioneering work in nucleic acids, which he shared with Frederick Sanger and Paul Berg. He has since been involved with the Human Genome Project, an international scientific research project to compile a complete map of the gene sequences in human DNA.
Professional position
- Chair, Society of Fellows, Harvard University
- Founder, Vice-Chairman, Myriad Genetics
- Carl M Loeb University Professor Emeritus, Department of Biochemistry and Molecular Biology, Harvard University
Subject groups
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Molecules of Life
Biochemistry and molecular biology
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Cell Biology
Genetics (excluding population genetics)
Awards
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Nobel Prize in Chemistry
Half of prize awarded jointly with Frederick Sanger for their contributions concerning the determination of base sequences in nucleic acids.
