Research Fellows Directory
Dr Werner Treptow
King's College London
Channels and transporters are ubiquitous membrane-embedded transport proteins (MTP), responsible for regulating the flux of water, ions and a wide range of molecules through cellular membranes. Their functioning underlies some of the most essential physiological processes, such as generation of gradients across cellular compartments, muscle and neuron electrical signaling, immune responses, etc. Several human pathologies involving syndromes, deafness, epilepsy and diabetes to name only few are caused by disruption of MTP genes. My group has been devoted to study these proteins' gating and conduction mechanisms using atomistic molecular dynamics simulations and free energy calculation methods. More recently, the acquired knowledge started to be applied across an entire range of novel investigations in both theoretical and experimental fronts, directed toward understanding MTP regulation by ligands, especially by toxins and anesthetics. Encouraged by the Newton Fellowship Award, we intend to start a profitable collaboration with the Domene group, and continue to contribute novel and relevant insights on the MTP biophysics field .
Interests and expertise (Subject groups)