Research Fellows Directory
Dr Wim Pierson
Upon infection or vaccination, germinal centre (GC) responses generate long-lived antibody secreting plasma cells and memory B cells. This allows vaccination programs to very efficiently halt or even eradicate life-threatening infectious diseases. Despite these advances in preventive medicine, protecting aged individuals against seasonal epidemics such as influenza has proven difficult as their ability to generate a robust, protective memory after vaccination is strongly reduced. My project will focus on the changes occurring during the aging process of the immune system, in particular those that impede the formation and function of protective structures such as the germinal centre.
Interests and expertise (Subject groups)