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Research Fellows Directory

Yang Wang

Dr Yang Wang

Research Fellow


University of Liverpool

Research summary

More than 90% of human genes undergo alternative splicing to generate protein diversity. Our main focus is to study how alternative splicing is regulated in a systematic level and how such regulation responds to cellular signaling pathways during key biological processes. In addition, we developed new approaches to manipulate splicing and other RNA processing pathways by engineering artificial factors that specifically recognize a given RNA target. In summary, my lab is seeking to solve the splicing code (i.e. a set of rules for splicing regulation by cis-elements and trans-factors) and to reprogram the code to control gene function. Since alternative splicing is a key regulatory mode for the majority of human genes and the splicing dysregulation is a common cause of various diseases, our research can provide important insight to fundamental biology and human diseases.

Grants awarded

Mechanistic study of the reduction of RBM4 in cancer and its role in regulating the oncogenic SRSF1

Scheme: Newton Advanced Fellowship

Dates: Mar 2015 - Mar 2018

Value: £111,000