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Research Fellows Directory

Yi Feng

Dr Yi Feng

Research Fellow

Organisation

University of Edinburgh

Research summary

It is likely that millions of cells in our body become cancerous everyday, yet most die and only a few escapees may become full blown cancer. How do these escapees interact with normal tissue such that it makes them become cancer? If we could visualize these interactions in real time and understand the underlining mechanisms it might lead to ways of preventing cancer from happening. I have used a zebrafish model, in which cancer cells (tagged with green fluorescence protein) start growing in sk in tissue at the larval stage. Using a fluorescence microscope, I film interactions between cancer cells (GREEN) and leukocytes (tagged with red fluorescence protein) and have found, for the first time, that leukocytes are attracted to cancer cells at their inception. But unexpectedly, instead of attacking cancer cells, leukocytes actually HELP in their growth by releasing trophic factors. I wish to understand how cancer cell talk to its normal neighbour and immune cells, and persuade immune cel ls to help the developm

Grants awarded

Live imaging and genetic analysis of the inflammatory response upon oncogene induced tissue homeostasis disruption and its contribution to tumour initiation in zebrafish larvae .

Scheme: Sir Henry Dale Fellowship

Dates: Feb 2013 - Feb 2018

Value: £988,921