Research Fellows Directory
Dr Yueru SUN
Imperial College London
My research ultimately aims to reveal structures and functions of potential drug targets in both human and pathogens. Information obtained in these experiments will provide the means to develop of novel chemotherapies towards various diseases, including tuberculosis, Parkinson’s disease and cancers. As part of the fellowship, I will explore the structure of PALB2, a key protein in the DNA double strand damage and repairing process. PALB2 is an important partner of BRCA1 and BRCA2 in formation of BRCA1, PALB2, BRCA2 tumour suppressor complex. Combination of X-ray crystallography, cryo-EM and other biophysical and biochemical methods will be involved in the structure and functional elucidation of the ternary complex. Elucidating the structures of the BRCA proteins and complexes will be mile-stones in understanding of DSBs repairing machinery. Furthermore, the results will provide an in-depth insight into the cause of BRCA-related hereditary breast/ovarian cancers.
Interests and expertise (Subject groups)