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Fellows Directory

Dennis Lo

Professor Dennis Lo FRS


Elected: 2011





Dennis Lo is a chemical pathologist who completely changed thinking on prenatal diagnosis by discovering that it was possible to pick up an unborn baby’s DNA and RNA in cell-free form from maternal blood. This development created a paradigm shift in prenatal medicine.

He was able to elucidate the fundamental biology of this phenomenon. He then developed multiple prenatal tests based on this technology that are now in widespread use around the world, including tests that allow robust prenatal and noninvasive testing for trisomy 21 — the chromosomal disorder responsible for Down syndrome. More recently, Dennis has shown that the foetal genome, methylome and transcriptome can all be sequenced from maternal blood.

Dennis has won many awards for his work, including the 2014 King Faisal International Prize in Medicine. He is also a Foreign Associate of the US National Academy of Sciences and a Fellow of The World Academy of Sciences.

Professional positions

Director, Li Ka Shing Institute of Health Sciences, Chinese University Of Hong Kong

Interests and expertise

Subject groups


Cancer detection and diagnosis, Clinical genetics, Molecular pathology, Pathology and laboratory medicine, Prenatal diagnosis