Research area - cell biology: cell signalling and membrane trafficking.
The cells in our bodies contain different membrane-bound compartments
constantly exchanging their membranes and other molecules in a highly regulated
manner. Proper control of membrane transport between these compartments is of
fundamental importance, and defects in these processes are a cause for many
types of diseases. It is therefore important to understand the players and the
mechanisms they exert to control membrane transport. Fibroblast Growth Factor
Receptor (FGFR) is a molecule located on the cell surface, which receives a
signal from outside the cell and transmits it to the inside of the cell. FGFR
mediated signalling is essential for several aspects in adult life and development,
and defects in signal transduction can cause multiple skeletal disorders and
cancers. We have found that attenuated FGFR signalling results in defective
membrane transport. By analysing how FGFR mediated signalling regulates
membrane transport we will gain a better understanding in how cell signalling and
membrane transport are coupled within the cell, which will help in the design of
new therapies to fight the diseases associated with the defects in both processes.