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Zita Balklava

Dr Zita Balklava

Dr Zita Balklava

Research Fellow

Grants awarded

Role of Fibroblast Growth Factor Receptor in regulation of membrane traffic.

Scheme: Dorothy Hodgkin Fellowship

Organisation: Aston University

Dates: Nov 2008-Jan 2014

Value: £425,375.20

Summary: Research area - cell biology: cell signalling and membrane trafficking. The cells in our bodies contain different membrane-bound compartments constantly exchanging their membranes and other molecules in a highly regulated manner. Proper control of membrane transport between these compartments is of fundamental importance, and defects in these processes are a cause for many types of diseases. It is therefore important to understand the players and the mechanisms they exert to control membrane transport. Fibroblast Growth Factor Receptor (FGFR) is a molecule located on the cell surface, which receives a signal from outside the cell and transmits it to the inside of the cell. FGFR mediated signalling is essential for several aspects in adult life and development, and defects in signal transduction can cause multiple skeletal disorders and cancers. We have found that attenuated FGFR signalling results in defective membrane transport. By analysing how FGFR mediated signalling regulates membrane transport we will gain a better understanding in how cell signalling and membrane transport are coupled within the cell, which will help in the design of new therapies to fight the diseases associated with the defects in both processes.

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