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Non-protein-coding RNAs - the DNA–RNA dialogue in shaping the transcriptome









The Royal Society, London, 6-9 Carlton House Terrace, London, SW1Y 5AG



Organised by Dr Andreas Werner, Professor Denise Barlow and Professor Kevin Morris

Transmission of genetic information is not a top-down process but rather a dialogue between DNA and RNA. Long and short non-protein-coding RNAs have recently emerged as important mediators of the genomic readout. The input of non-protein-coding RNAs is essential to shaping transcriptional output and correlates with organismal complexity. Moreover, interruption of RNA-mediated feedback perturbs gene expression and can result in human disease.

Programme available to download here (PDF). 

Biographies and audio recordings are available below.

Event organisers

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Schedule of talks

Session 1

6 talks Show detail Hide detail

The complexity of the mammalian transcriptome

Dr Piero Carninci, RIKEN Yokohama Institute, Japan

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Important lessons from the transcriptomes of complex genomes

Dr Thomas Gingeras, Cold Spring Harbor Laboratory, USA

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RNA at the epicentre of development and cognition

Professor John Mattick, The Garvan Institute of Medical Research, Australia

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Large intergenic noncoding RNAs (lincRNAs): from parasites to pluripotency a panoply of functional roles

Professor John Rinn, Harvard University, USA

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The long and small of ncRNA gene nomenclature

Dr Matt Wright, European Bioinformatics Institute, UK

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Mechanisms of discordant and concordant natural antisense regulation of gene expression

Professor Claes Wahlestedt, University of Miami, USA

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Session 2

5 talks Show detail Hide detail

Noncoding RNA targets chromatin modifying enzymes to regulatory gene sequences

Professor Ingrid Grummt, German Cancer Research Center, Heidelberg, Germany

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RNA-directed DNA methylation in Arabidopsis

Dr Zdravko Lorkovic, Gregor Mendel Institute of Molecular Plant Biology, Austria

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Linking RNA surveillance and genome stability

Professor David Tollervey FRS, University of Edinburgh, UK

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Emerging roles of RNA interference in genome regulation

Dr Marc Bühler, Friedrich Miescher Institute for Biomedical Research, Switzerland

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Do pseudogenes function as master non-coding RNA regulators of gene expression in human cells?

Professor Kevin Morris, University of New South Wales, Australia

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Session 3

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Regulatory RNAs in bacteria: biological roles, molecular mechanisms, protein involvement

Professor E. Gerhart H. Wagner, Uppsala University, Sweden

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Convergent transcription and the induction of transcriptional gene silencing in eukaryotes

Dr Monika Gullerova and Professor Nicholas Proudfoot FRS, University of Oxford, UK

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Macro ncRNAs in imprinted gene clusters in the mouse and human genome

Professor Denise Barlow, Research Center for Molecular Medicine of the Austrian Academy of Science, Austria

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The role of non-coding RNAs in regulating X-chromosome inactivation

Professor Edith Heard FRS, Institut Curie and Collège de France, France

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What are natural antisense transcripts good for?

Dr Andreas Werner, Newcastle University, UK

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Non-protein-coding RNAs - the DNA–RNA dialogue in shaping the transcriptome

Theo Murphy international scientific meeting organised by Dr Andreas Werner, Professor Denise Barlow and Professor Kevin Morris.

The Royal Society, London 6-9 Carlton House Terrace London SW1Y 5AG UK
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