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Regulation of gene expression from a distance: exploring mechanisms

  • 24 - 25 October 2012, 09:00 - 16:00
Add to Calendar 10/24/12 09:00 AM 10/25/12 04:00 PM United Kingdom (GMT) Regulation of gene expression from a distance: exploring mechanisms <p>Regulation of gene expression from a distance: exploring mechanisms</p> Newport Pagnell, Buckinghamshire, MK16 9JJ
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Overview Organisers Programme

Overview

Satellite meeting organised by Professor Wendy Bickmore and Professor Veronica van Heyningen FRS

Event details

How do distant regulatory elements (enhancers) control spatial and temporal patterns of expression of target genes? This meeting aims to integrate experimental and computational approaches that explore mechanisms of quantitative control of gene expression by enhancers in different model systems. Bringing together researchers from multiple disciplines will provoke new avenues of investigation into long-range gene regulation.

Biographies of the organisers and speakers are available below. Audio recordings are freely available and the programme can be downloaded here.

This meeting was preceded by the related Discussion meeting Regulation from a distance: long-range control of gene expression in development and disease 22 - 23 October 2012.

Enquiries: Contact the events team.

Organisers

Professor Wendy Bickmore, University of Edinburgh, UK

Professor Wendy Bickmore, University of Edinburgh, UK

Wendy Bickmore is the Head of the Chromosomes and Gene Expression Section at the MRC Human Genetics Unit, MRC IGMM at the University of Edinburgh. Her scientific work is based on the principle being that genes do not function in isolation from their chromosomal and nuclear context. She has pioneered research into the spatial and temporal organisation of the human and mouse genomes, and the implications of this for gene regulation and genome function. Her experimental approaches combine cell biology with genomics, genetics and biochemistry. Wendy is an EMBO member, and a Fellow of both the Royal Society of Edinburgh and the Academy of Medical Sciences.

Professor Veronica Van Heyningen FRS, University of Edinburgh, UK

Professor Veronica Van Heyningen FRS, University of Edinburgh, UK

"Veronica van Heyningen, formerly Head of the Medical and Developmental Genetics Section, is a Group Leader at the MRC Human Genetics Unit, MRC IGMM at the University of Edinburgh.  The group’s work with human developmental disease brought insight into the mechanisms of cis-regulatory control, revealing the long control regions flanking many developmental regulator genes.  Studies of extra-genic chromosomal rearrangements and non-coding region mutations prompted work, in mouse and zebrafish model systems, on enhancer interactions and transcription factor binding specificity.  Genome-wide target predictions for PAX6 have revealed network complexity and the precision of target-sequence specificity.  Veronica was appointed a CBE for services to science, is an EMBO Member and a Fellow of the Royal Society of Edinburgh, the Academy of Medical Sciences and of the Royal Society."

Schedule