All the organs of our body originate from small founder populations of cells which multiply into complex structures. Adult stem cells are used to maintain organs throughout adult life and to repair or regenerate them after damage. Focusing on the lung, an organ that is frequently damaged by disease and environmental agents, this talk examined mechanisms controlling the differentiation and morphogenesis of embryonic organs, the behaviour of adult stem cells, and how these are influenced by factors including genes, ageing, inflammation and infection.
Brigid Hogan FRS is the George Barth Geller Professor and Chair of the Department of Cell Biology, Duke University Medical Center. She is a past-president of the American Society for Developmental Biology and the American Society of Cell Biology, was co-chair for science of the 1994 NIH human embryo research panel and a member of the 2001/02 National Academies panel on scientific and medical aspects of human cloning. She was awarded the 2014 Croonian Lecture for her pioneering contributions that have transformed understanding of cell specification, organogenesis and morphogenesis in mammalian development.
The Croonian Lecture is the Royal Society's premier lecture in biological sciences. It is delivered annually at the Royal Society in London and is accompanied by a medal and a gift of £1,000.
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